{"id":47831,"date":"2024-04-23T14:02:22","date_gmt":"2024-04-23T06:02:22","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47831"},"modified":"2024-04-23T14:02:22","modified_gmt":"2024-04-23T06:02:22","slug":"guanidine-hydrochloride","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47831","title":{"rendered":"Guanidine hydrochloride","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47829\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/e4f046dadc55454b93aa750b5d9ab0b7-7.gif\" width=\"227\" height=\"170\" alt=\"Guanidine hydrochloride structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>0132<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>CH6ClN3<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>95.53<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         Carbamidamidine hydrochloride,<\/p>\n<p>                         Genetic engineering research reagents<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>50-01-1<\/p>\n<p><b>MDL number:<\/b>MFCD00013026<\/p>\n<p><b>EINECS number:<\/b>200-002-3<\/p>\n<p><b>RTECS number:<\/b>MF4300000<\/p>\n<p><b>BRN number:<\/b>3591990<\/p>\n<p><b>PubChem ID:<\/b>None<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: white or slightly yellow lumps<\/p>\n<p>2. Melting point (\u2103): 181-183 <\/p>\n<p>3. Relative density (g\/mL, 20\/4  \u2103): 1.354 <\/p>\n<p>4. Solubility: 228g can be dissolved in 100g water at 20\u2103, 76g can be dissolved in 100g methanol, and 24g can be dissolved in 100g ethanol.  Almost insoluble in acetone, benzene and ether.  <\/p>\n<p>5. PH value (4% aqueous solution, 25\u2103): 6.4 <\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     <span style=\"font-family:Arial\">The oral LD50 for rabbits is 500mg\/kg.  For protective methods, see thiosemicarbazide.  <br \/><\/span>\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 12.89<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 37.9<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 114.4<\/p>\n<p>4. Surface tension (dyne\/cm): 82.9<\/p>\n<p>5. Polarizability (10-24cm3): 5.11<\/p>\n<\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     <span style=\"font-family:Arial\">This product is relatively unstable and can <span style=\"font-family:Arial\"> be hydrolyzed in aqueous solution to form ammonia and urea, so its toxicity is the same as that of urea.  Its derivatives are generally more toxic than ureas.  <br \/><\/span><\/span>\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     Using dicyandiamide and ammonium salt (ammonium chloride) as raw materials, conduct a melting reaction at 170-230\u00b0C to obtain crude guanidine hydrochloride, which can be refined to obtain the finished product.  <img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47830\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/201010151608554110-7.gif\" width=\"249\" height=\"37\" alt=\"\" \/>\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>1. Can be used as intermediates for medicines, pesticides, dyes and other organic synthesis.  It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methylpyrimidine, 2-amino-4,6-dimethylpyrimidine, and is used to manufacture sulfa drugs such as sulfadiazine, sulfamethylpyrimidine, and sulfadimethylpyrimidine.  intermediate.  <\/p>\n<p>2. Guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate to form 2,4-diamino-6-hydroxypyrimidine, which is used to synthesize the anti-anemia drug folic acid.  It can also be used as an antistatic agent for synthetic fibers.  <\/p>\n<p>3. It can also be used as a protein denaturant.  <\/p>\n<\/p>\n<p>     extended-reading:https:\/\/www.newtopchem.com\/archives\/938<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/134<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/39156<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/strong-gel-amine-catalyst-ne500-dabco-strong-gel-amine-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/u-cat-5002-catalyst-cas126741-28-8-sanyo-japan\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/45164<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/677<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/-RP205-Addocat-9727P-high-efficiency-amine-catalyst.pdf<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/07\/123-1.jpg<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/N-Formylmorpholine-CAS4394-85-8-4-formylmorpholine.pdf<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 0132 Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47830,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[6810],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47831"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47831"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47831\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47830"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47831"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}