{"id":47835,"date":"2024-04-23T14:02:39","date_gmt":"2024-04-23T06:02:39","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47835"},"modified":"2024-04-23T14:02:39","modified_gmt":"2024-04-23T06:02:39","slug":"hydrocortisone-acetate","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47835","title":{"rendered":"hydrocortisone acetate","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47834\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/6f59035a930c4e0faedf476e39805301-6.gif\" width=\"252\" height=\"131\" alt=\"Structural formula of hydrocortisone acetate\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>0134<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C23H32O6<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>404.5<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         Hydrocortisone-21-acetate,<\/p>\n<p>                         hydrocortisone acetate,<\/p>\n<p>                         hydrocortisone acetate,<\/p>\n<p>                         ifosfamide,<\/p>\n<p>                         Hydrocorticosterone acetate,<\/p>\n<p>                         Acetate Hydrogenated Adrenocortical Hormone,<\/p>\n<p>                         21-Hydrocortisone acetate,<\/p>\n<p>                         Cortisol acetate,<\/p>\n<p>                         Hydrocortisone-21-acetate,<\/p>\n<p>                         Cortisol 21-acetate,<\/p>\n<p>                         21-Acetoxy-4-pregnene-11b,17a-diol-3,20-dione,<\/p>\n<p>                         17-\u03b1-Hydroxycorticosterone acetate,<\/p>\n<p>                         17-Hydroxycorticosterone 21-acetate,<\/p>\n<p>                          21-Acetoxy-4-pregnene-11\u03b2,<\/p>\n<p>                         17\u03b1-diol-3,20-dione, 4-Pregnene-11\u03b2,<\/p>\n<p>                         17\u03b1,21-triol-3,20-dione 21-acetate, 11\u03b2,<\/p>\n<p>                         hormone,<\/p>\n<p>                         antirheumatic drugs,<\/p>\n<p>                         anti-inflammatory drugs<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>50-03-3<\/p>\n<p><b>MDL number:<\/b>MFCD00037714<\/p>\n<p><b>EINECS number:<\/b>200-004-4<\/p>\n<p><b>RTECS number:<\/b>GM8960000<\/p>\n<p><b>BRN number:<\/b>2066841<\/p>\n<p><b>PubChem number:<\/b>24895620<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: White or off-white crystalline powder, odorless<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Undetermined<\/p>\n<p>3. Relative  Vapor density (g\/mL, air=1): Undetermined<\/p>\n<p>4. Melting point (\u00baC): 222-225\u00b0C.  <\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Undetermined<\/p>\n<p>6. Boiling point (\u00baC, 5.2kPa): Undetermined<\/p>\n<p>7. Refractive index:  Undetermined<\/p>\n<p>8. Flash point (\u00baC): 223<\/p>\n<p>9. Specific rotation (\u00ba): [\u03b1]<sup>25<\/sup><sub>D<\/sub>+166\u00b0<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n<p>11. Vapor pressure (kPa, 25\u00baC): Undetermined<\/p>\n<p>12. Saturated vapor pressure (kPa, 60\u00baC): Undetermined<\/p>\n<p>13. Heat of combustion (KJ\/mol): Undetermined<\/p>\n<p>14. Critical temperature (\u00baC):  Undetermined<\/p>\n<p>15. Critical pressure (KPa): Undetermined<\/p>\n<p>16. Log value of oil-water (octanol\/water) partition coefficient: Undetermined<\/p>\n<p>  17. Explosion upper limit (%, V\/V): Undetermined<\/p>\n<p>18. Explosion lower limit (%, V\/V): Undetermined<\/p>\n<p>19. Dissolution.\ufffd\ufffd\uff1aUndetermined<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p><p>Acute toxicity: Rat subcutaneous LDL0: 250 mg\/kg; mouse abdominal LD50: 2300 mg\/kg; mouse subcutaneous LD50: 45050 ug\/kg.  <\/p>\n<p>2. Subacute toxicity<\/p>\n<p>Rat subcutaneous oral TDL0: 175 mg\/kg\/35D-I <\/p>\n<p>3. Teratogenicity: mouse test  : 60 mg\/kg, DNA damage; 150 mg\/kg, gene mutation.  <\/p>\n<p>4. Reproductive toxicity<\/p>\n<p>Rat TDLo: 1 mg\/kg, fetal growth retardation; Rat TDLo: 1500 mg\/kg, fetal death;<\/p>\n<p>Rat abdominal TDLo: 2 mg\/kg, embryonic death; Rat subcutaneous TDLo: 350 mg\/kg, fetal growth retardation<\/p>\n<p>Mouse caliber TDLo: 125 mg\/kg, fetal growth retardation; small  Mouse subcutaneous TDLo: 250 mg\/kg, fetal death;<\/p>\n<p>Mouse subcutaneous TDLo: 75 mg\/kg, fetal development retardation; Mouse subcutaneous TDLo: 84 mg\/kg, fetal development retardation<\/p>\n<p>Mouse muscle TDLo: 64mg\/kg, little effect; mouse muscle TDLo: 320mg\/kg; malformation<\/p>\n<p>Mouse intestinal TDLo: 200 mg\/kg;<\/p>\n<p>  Rabbit caliber TDLo: 13 mg\/kg <\/p>\n<p>Pig muscle TDLo: 100 mg\/kg\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     Other harmful effects: This substance is harmful to the environment and special attention should be paid to water bodies.  are hazardous items.\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 103.75<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 318.1<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 858.0<\/p>\n<p>4. Surface tension (dyne\/cm): 52.8<\/p>\n<p>5. Polarizability (10-24cm3): 41.13<\/p>\n<\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): 2.2<\/p>\n<p>2. Number of hydrogen bond donors: 2<\/p>\n<p>3. Number of hydrogen bond acceptors: 6<\/p>\n<p>4. Number of rotatable chemical bonds: 4<\/p>\n<p>5. Number of tautomers: 10<\/p>\n<p>6. Topological molecular polar surface area (TPSA): 101<\/p>\n<p>7. Number of heavy atoms: 29<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 786<\/p>\n<p>10. Number of isotope atoms  : 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 7<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the chemical bond configuration  Number of centers: 0<\/p>\n<p>14, Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15, Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p><p>White or off-white crystalline powder, odorless.  Mp218-221.5\u2103; Specific optical rotation [\u03b1] 25D+166\u00b0 (dioxane); ethanol solution has maximum absorption at the wavelength of 240nm.  Insoluble in water, slightly soluble in ethanol (1:230) and chloroform (1:150), hardly soluble in ether.  <\/p>\n<\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     Store at 0-6 \u00baC in a dark, sealed container.\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p><p>Using C3-C5 aliphatic ketone as solvent, adding a certain amount of acetate, it is synthesized from hydrocortisone, acetic acid and acetic anhydride.  <\/p>\n<\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>Mainly used to treat rheumatoid arthritis, rheumatic fever, gout, bronchial asthma, etc.  Injections are used for tuberculous or purulent meningitis, tuberculous pleurisy, empyema, arthritis, tenosynovitis, tendon strain, sprain, nodular prurigo, lichen planus, etc.  Eye drops are used for various types of ophthalmia.  Creams are used for allergic or seborrheic dermatitis, pruritus, etc.  <\/p>\n<\/p>\n<p>     extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/102-4.jpg<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44779<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1093<\/br>extended-reading:https:\/\/www.bdmaee.net\/dmcha\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/nt-cat-t45l-catalyst-cas121-143-5-newtopchem\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44034<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40012<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/42953<\/br>extended-reading:https:\/\/www.bdmaee.net\/niax-ef-700-tertiary-amine-catalyst-momentive\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1159<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 0134 Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47834,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[10054],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47835"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47835"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47835\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47834"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47835"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}