{"id":47839,"date":"2024-04-23T14:02:54","date_gmt":"2024-04-23T06:02:54","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47839"},"modified":"2024-04-23T14:02:54","modified_gmt":"2024-04-23T06:02:54","slug":"mitomycin-c","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47839","title":{"rendered":"Mitomycin C","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47838\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/9c67b088ec0c4980a07f38675a3b526d-5.gif\" width=\"195\" height=\"160\" alt=\"Mitomycin C structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>0136<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C15H18N4O5<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>334.33<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         Mitomycin,<\/p>\n<p>                         mitomycin,<\/p>\n<p>                         Zilinomycin,<\/p>\n<p>                         Pyrimycin,<\/p>\n<p>                         [1aR-(1a\u03b1,8\u03b2,8a\u03b1,8b\u03b1)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-  methylazirino[2&#8242;,3&#8242;:3,4]pyrrolo[1,2-\u03b1]indole-4,7-dione,<\/p>\n<p>                         6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methox-5-methylazirino[2&#8242;,3&#8242;:3,4]pyrrolo[1,2-,<\/p>\n<p>                         antineoplastic drugs,<\/p>\n<p>                         antibiotic<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>50-07-7<\/p>\n<p><b>MDL number:<\/b>MFCD00078109<\/p>\n<p><b>EINECS number:<\/b>200-008-6<\/p>\n<p><b>RTECS number:<\/b>None<\/p>\n<p><b>BRN number:<\/b>7231816<\/p>\n<p><b>PubChem number:<\/b>24896555<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: blue-purple shiny crystals or crystalline powder, odorless.  The solid is stable, but easily deactivated in acidic and alkaline solutions<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Uncertain<\/p>\n<p>3. Relative vapor density (  g\/mL, air=1): Uncertain<\/p>\n<p>4. Melting point (\u00baC): &gt;360<\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Uncertain<\/p>\n<p>6. Boiling point (\u00baC, 5.2 kPa): Uncertain<\/p>\n<p>7. Refractive index: Uncertain<\/p>\n<p>8. Flash point (\u00baC): Uncertain<\/p>\n<p>9. Specific optical rotation (\u00ba): Uncertain<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Uncertain<\/p>\n<p>11. Vapor pressure (kPa, 25  \u00baC): Uncertain<\/p>\n<p>12. Saturated vapor pressure (kPa, 60 \u00baC): Uncertain<\/p>\n<p>13. Heat of combustion (KJ\/mol): Uncertain<\/p>\n<p>14. Critical temperature (\u00baC): Uncertain<\/p>\n<p>15. Critical pressure (KPa): Uncertain<\/p>\n<p>16. Log value of oil-water (octanol\/water) partition coefficient  : Uncertain<\/p>\n<p>17. Explosion upper limit (%, V\/V): Uncertain<\/p>\n<p>18. Explosion lower limit (%, V\/V): Uncertain<\/p>\n<p>19. Solubility: This product is soluble in water (H<sub>2<\/sub>O: 4 mL\/vial Stock solutions should be filter sterilized and stored at 2-8 \u00b0C in the dark., clear to slightly  hazy, blue to purple), methanol, acetone and ethyl acetate and other organic solvents, slightly soluble in benzene, diethyl ether and carbon tetrachloride, but insoluble in petroleum ether<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">MinsSubstructure data<\/h2>\n<p><p>1. Molar refractive index: 80.79<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 213.6<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 633.5<\/p>\n<p>4. Surface tension (dyne\/cm): 77.2<\/p>\n<p>5. Polarizability (10-24cm3): 32.02<\/p>\n<\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Hydrophobic parameter calculation reference value (XlogP): -0.4<\/p>\n<p>2. Number of hydrogen bond donors: 3<\/p>\n<p>3. Number of hydrogen bond acceptors: 8<\/p>\n<p>  p&gt;<\/p>\n<p>4. Number of rotatable chemical bonds: 4<\/p>\n<p>5. Number of tautomers: 42<\/p>\n<p>6. Topological molecular polar surface area (TPSA): 147<\/p>\n<p>7. Number of heavy atoms: 24<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 757<\/p>\n<p>10. Isotopic atoms  Quantity: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 4<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine chemical bond positions  Number of stereocenters: 0<\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>This product should be sealed and stored in a cool, dark place.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p><p>Produced by fermentation method.  Mitomycin A, B, and C can be extracted from the culture medium of Strepto-myces caespitosus.  my country extracted it from its own isolate of actinomycete H2760 strain, also known as Zilinomycin, which is the same as mitomycin C reported abroad.  <\/p>\n<\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>This product has a wide anti-tumor spectrum and is effective in gastric cancer and breast cancer.  It has certain effects on lung cancer, liver cancer, malignant lymphoma, Hodgkin&#8217;s disease, reticulocyte sarcoma, uterine cancer, leukemia, intestinal cancer and pancreatic cancer, but the remission period is short.  Combination with urokinase can improve the efficacy. This product acts quickly, but the number of treatment operators is not high and the toxicity is high.  This product, along with bleomycin and its derivatives perimecin, are antibiotic anticancer drugs that damage DNA. They can depolymerize cellular DNA and inhibit DNA replication in proliferating cells.  The LD50 of intravenous injection in mice is 5ml\/kg.  <\/p>\n<\/p>\n<p>     extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/22.jpg<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/semi-rigid-foams-catalyst<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/Polyurethane-Catalyst-A33-CAS-280-57-9&#8211;33-LV.pdf<\/br>extended-reading:https:\/\/www.bdmaee.net\/nt-cat-e-129-elastomer-catalyst-elastomer-catalyst-nt-cat-e-129\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/dibutyloxostannane\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/methyl-tin-maleate-powder\/<\/br>extended-reading:https:\/\/www.morpholine.org\/category\/morpholine\/flumorph\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/fomrez-ul-28-catalyst-dimethyltin-dioctadecanoate-momentive-2\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/tertiary-amine-catalyst-xd-103-catalyst-xd-103\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40000<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 0136 Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47838,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[6658],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47839"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47839"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47839\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47838"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47839"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}