{"id":47885,"date":"2024-04-23T15:06:02","date_gmt":"2024-04-23T07:06:02","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47885"},"modified":"2024-04-23T15:06:02","modified_gmt":"2024-04-23T07:06:02","slug":"chlopromazine-hydrochloride","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47885","title":{"rendered":"Chlopromazine hydrochloride","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47884\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/6f2cefc5acc64da18b7e48d76621aa29-1.gif\" width=\"238\" height=\"235\" alt=\"Structural formula of chlorpromazine hydrochloride\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>01FJ<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C17H20Cl2N2S<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>355.34<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride,<\/p>\n<p>                         hibernation spirit,<\/p>\n<p>                         Colagent,<\/p>\n<p>                         Chlorpromazine,<\/p>\n<p>                         aminazine,<\/p>\n<p>                         chlorpromazine,<\/p>\n<p>                         Chlorpromazine hydrochloride,<\/p>\n<p>                         Hibernating phosphorus,<\/p>\n<p>                         C17H19ClN2S\u00b7HCl<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>69-09-0<\/p>\n<p><b>MDL number:<\/b>MFCD00012654<\/p>\n<p><b>EINECS number:<\/b>200-701-3<\/p>\n<p><b>RTECS number:<\/b>200-701-3<\/p>\n<p><b>BRN number:<\/b>3779989<\/p>\n<p><b>PubChem number:<\/b>24277891<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>1.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Character:<\/SPAN><SPAN>White or milky white crystalline powder, hygroscopic, slightly odorous, extremely bitter in taste, easily oxidized in air or  Gradates to reddish brown in sunlight<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>2.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Density (<\/SPAN><SPAN>g\/mL,25\/4<\/SPAN><SPAN>\u2103<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>3.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Relative vapor density (<\/SPAN><SPAN>g\/mL,<\/SPAN><SPAN>AIR<\/SPAN><SPAN>=1<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>4.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Melting point (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>):<\/SPAN><SPAN>179-180<SPAN><SPAN>\u2103<\/SPAN><\/SPAN><\/SPAN><SPAN>\uff08  <\/SPAN><SPAN>194-196<SPAN><SPAN>\u2103<\/SPAN><\/SPAN>  <\/SPAN><SPAN>).  <\/SPAN><SPAN><\/SPAN>  <\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>5.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Boiling point (<\/SPAN><SPAN>\u00baC,<\/SPAN><SPAN>Normal pressure): Uncertain<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>6.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Boiling point (<\/SPAN><SPAN>\u00baC, 5.2kPa<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>7.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Refractive index:<\/SPAN><SPAN>Not sure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>8.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Flash point (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>9.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Specific optical rotation (<\/SPAN><SPAN>\u00ba<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>10.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Autoignition point or ignition temperature (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): No\ufffd\ufffddetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>11.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Vapor pressure (<\/SPAN><SPAN>kPa,25\u00baC<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>12.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Saturated vapor pressure (<\/SPAN><SPAN>kPa,60\u00baC<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>13.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Heat of combustion (<\/SPAN><SPAN>KJ\/mol<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>14.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Critical temperature (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>15.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Critical pressure (<\/SPAN><SPAN>KPa<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>16.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Oil and water (octanol<\/SPAN><SPAN>\/<\/SPAN><SPAN>Log value of water) partition coefficient: Uncertain<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>17.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Explosion limit (<\/SPAN><SPAN>%,V\/V<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>18.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Lower explosion limit (<\/SPAN><SPAN>%,V\/V<\/SPAN><SPAN>): Unsure<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>19.<SPAN> <\/SPAN>  <\/SPAN><\/SPAN><SPAN>Solubility:<\/SPAN><SPAN>Easily soluble in water, ethanol, chloroform, insoluble in ether and benzene<\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n<p>2. Number of hydrogen bond donors: 1<\/p>\n<p>3. Number of hydrogen bond acceptors: 3<\/p>\n<p>4. Number of rotatable chemical bonds: 4<\/p>\n<p>5. Number of tautomers: none<\/p>\n<p>6. Topological molecule polar surface area 31.8<\/p>\n<p>7. Number of heavy atoms: 22<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 339<\/p>\n<p>10. Isotopic origin\ufffdQuantity: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 0<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine chemical bonds  Number of stereocenters: 0<\/p>\n<p>14. Number of stereocenters of uncertain chemical bonds: 0<\/p>\n<p>15. Number of covalent bond units: 2<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN>Keep it sealed and protected from light.  <\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN>By<\/SPAN><SPAN>2-<\/SPAN><SPAN>Chlorophenothiazine<\/SPAN><SPAN>[92-39-7]<\/SPAN><SPAN>Condensation and salt formation.  <\/SPAN><SPAN>1.<\/SPAN><SPAN>Condensation in reaction  Add <\/SPAN><SPAN>2-<\/SPAN><SPAN style=\"FONT\">  Chlorophenothiazine and toluene, then add sodium hydroxide, stir and heat to reflux, remove moisture, and in <\/SPAN><SPAN>110<\/SPAN><SPAN>\u2103 dripping<\/SPAN><SPAN>1-<\/SPAN><SPAN>Chlorine<\/SPAN><SPAN>-3-<\/SPAN><SPAN>Toluene solution of dimethylaminopropane, the reactant is decompressed to recover toluene to obtain chlorpromazine,<\/SPAN><SPAN>C17H19CIN2S<\/SPAN><SPAN>,<\/SPAN><SPAN>[50-53-3]<\/SPAN><SPAN>.  <\/SPAN><SPAN>2.<\/SPAN><SPAN>Salt<\/SPAN><SPAN> <\/SPAN><SPAN>Stir and heat chlorpromazine and isopropyl alcohol until  <\/SPAN><SPAN>40<\/SPAN><SPAN>\u2103, access  dry hydrogen chloride to pH 4-5<\/SPAN><SPAN>, and the chlorpromazine hydrochloride is obtained as a salt.  <\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN>has central stabilizing, antiemetic, anticonvulsant, anti-  Adrenaline and other effects.  Used to treat schizophrenia and mania.  Anxiety disorders, mental disorders, nausea, vomiting, etc.  It can also be used for artificial hibernation and low-temperature anesthesia.  <\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN> <\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<p>     extended-reading:https:\/\/www.bdmaee.net\/fascat9201-catalyst-dibutyl-tin-oxide-fascat9201\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/45168<\/br>br&gt;extended-reading:https:\/\/www.newtopchem.com\/archives\/40312<\/br>extended-reading:https:\/\/www.bdmaee.net\/nt-cat-ea-33-catalyst-cas280-57-9-newtopchem\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/18-Diazabicycloundec-7-ene-CAS-6674-22-2-DBU.pdf<\/br>extended-reading:https:\/\/www.morpholine.org\/category\/morpholine\/other-products\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/n-butyltintrichloridemin-95\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/dabco-t-9-catalyst-cas29568-56-9-evonik-germany\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/41<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44333<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 01FJ Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47884,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15046],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47885"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47885"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47885\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47884"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47885"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}