{"id":47887,"date":"2024-04-23T15:07:39","date_gmt":"2024-04-23T07:07:39","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47887"},"modified":"2024-04-23T15:07:39","modified_gmt":"2024-04-23T07:07:39","slug":"fluphenazine","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47887","title":{"rendered":"Fluphenazine","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47886\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/e1403a4fd16d46dfbc4a9abeb8e7bfba-1.gif\" width=\"339\" height=\"231\" alt=\"Fluphenazine Structural Formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>01FK<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C22H26F3N3OS<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>437.52<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         fluphenazine,<\/p>\n<p>                         Hydroxyflupromazine,<\/p>\n<p>                         flupheperazine,<\/p>\n<p>                         guitarmycin<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>69-23-8<\/p>\n<p><b>MDL number:<\/b>None<\/p>\n<p><b>EINECS number:<\/b>None<\/p>\n<p><b>RTECS number:<\/b>None<\/p>\n<p><b>BRN number:<\/b>None<\/p>\n<p><b>PubChem ID:<\/b>None<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Character: dark brown viscous oil<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Uncertain<\/p>\n<p>3. Relative vapor density (g  \/mL, air=1): Uncertain<\/p>\n<p>4. Melting point (\u00baC): 225~227 (decomposition).  <\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Uncertain<\/p>\n<p>6. Boiling point (\u00baC, 5.2kPa): Uncertain<\/p>\n<p>7. Refractive index:  Uncertain<\/p>\n<p>8. Flash point (\u00baC): Uncertain<\/p>\n<p>9. Specific rotation (\u00ba): Uncertain<\/p>\n<p>10. Autoignition point or ignition  Combustion temperature (\u00baC): Uncertain<\/p>\n<p>11. Vapor pressure (kPa, 25\u00baC): Uncertain<\/p>\n<p>12. Saturated vapor pressure (kPa, 60\u00baC): Uncertain<\/p>\n<p>13. Heat of combustion (KJ\/mol): Uncertain<\/p>\n<p>14. Critical temperature (\u00baC): Uncertain<\/p>\n<p>15. Critical pressure (KPa): Uncertain  <\/p>\n<p>16. The logarithmic value of the oil-water (octanol\/water) partition coefficient: Uncertain<\/p>\n<p>17. The upper limit of explosion (%, V\/V): Uncertain<\/p>\n<p>18. Lower explosion limit (%, V\/V): Uncertain<\/p>\n<p>19. Solubility: Easily soluble in water, slightly soluble in methanol, slightly soluble in ethanol and chloroform, almost insoluble in benzene and  Ether.  Hygroscopic<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     Acute toxicity: Rat intraperitoneal LD50: 100 mg\/kg; Rat subcutaneous injection LD50: 640 mg\/kg; Mouse oral LD50: 220 mg\/kg; Mouse intraperitoneal LD50: 89 mg\/kg; Mouse intravenous LD50:  51 mg\/kg; Breeding: Rat oral TDLo: 62 mg\/kgSEX\/DURATION: female 9 day(s) pre-mating female 1-22 day(s) after conception; Rat oral TDLo: 18 mg\/kgSEX  \/DURATION: female 9 day(s) pre-mating;\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 114.30<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 343.8<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 885.9<\/p>\n<p>4. Surface tension (dyne\/cm): 44.0<\/p>\n<p>5. Polarizability (10-24cm3): 45.31<\/p>\n<\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n<p>2. Number of hydrogen bond donors: 1<\/p>\n<p>3. Number of hydrogen bond acceptors: 8<\/p>\n<p>4. Number of rotatable chemical bonds: 6<\/p>\n<p>5. Number of tautomers: none<\/p>\n<p>6. Topological molecule polar surface area 55.2<\/p>\n<p>7. Number of heavy atoms: 30<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 544<\/p>\n<p>10. Number of isotope atoms: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 0<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the number of chemical bond stereocenters: 0  <\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>This product should be stored in an airtight container away from light.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p><p>It is produced by alkylation of hydroxyethylpiperazine and bromochloropropane and then condensation with 2-trifluoromethylphenothiazine to form a salt.  It can also be obtained by condensation, elimination, cyclization, etc. of m-trifluoromethylaniline.  <\/p>\n<\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     Antipsychotics.  It is clinically used for catatonic and paranoid schizophrenia, and is more effective than chlorpromazine for chronic schizophrenia.  Preparations include tablets and injections\n     <\/p>\n<p>     extended-reading:https:\/\/www.newtopchem.com\/archives\/44468<\/br>extended-reading:https:\/\/www.bdmaee.net\/dabco-25-s-catalyst-cas280-57-9-evonik-germany\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/cas23850-94-4\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/115-5.jpg<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/delayed-catalyst-mp601-dabco-mp601-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2020\/06\/67.jpg<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/661<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/640<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/45025<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/134-1.jpg<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 01FK Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47886,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15047],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47887"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47887"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47887\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47886"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47887"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}