<\/p>\n
Structural formula<\/p>\n
2-Aminothiazol<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
CAS number:<\/b>96-50-4<\/p>\n
MDL number:<\/b>MFCD00005325<\/p>\n
EINECS number:<\/b>202-511-6<\/p>\n
RTECS number:<\/b>XJ2100000<\/p>\n
BRN number:<\/b>105738<\/p>\n
PubChem number:<\/b>24846344<\/p>\nPhysical property data<\/h2>\n
1. Properties: White to yellow crystals, gradually turning dark brown when exposed to air, easily sublimating. <\/p>\n
2. Density (g\/mL, 20\u2103): Undetermined<\/p>\n
3. Relative vapor density (g\/mL, air=1): Undetermined<\/p>\n
4. Melting point (\u00baC): 90<\/p>\n
5. Boiling point (\u00baC, normal pressure): Undetermined <\/p>\n
6. Boiling point (\u00baC, 1.46kPa): 140<\/p>\n
7. Refractive index: Undetermined<\/p>\n
8. Flash point (\u00baC): Undetermined<\/p>\n
9. Specific rotation (\u00ba): Undetermined<\/p>\n
10. Autoignition point or ignition temperature (\u00baC): Not determined<\/p>\n
11. Vapor pressure (mmHg,\u00baC): Not determined<\/p>\n
12. Saturated vapor pressure (kPa , \u00baC): Undetermined<\/p>\n
13. Heat of combustion (KJ\/mol): Undetermined<\/p>\n
14. Critical temperature (\u00baC): Undetermined<\/p>\n
15 . Critical pressure (KPa): Undetermined<\/p>\n
16. Log value of oil-water (octanol\/water) distribution coefficient: Undetermined<\/p>\n
17. Explosion upper limit (%, V\/V ): Undetermined<\/p>\n
18. Lower explosion limit (%, V\/V): Undetermined<\/p>\n
19. Solubility: Slightly soluble in cold water, ethanol, easily soluble in hot water, Dilute inorganic acid. <\/p>\n<\/p>\n
\n 1. Acute toxicity: rat oral LD50: 480mg\/kg; rat intravenous LD50: 570mg\/kg; mouse peritoneal cavity LD50: 200mg\/kg; cat oral LD50: 120mg\/kg; rabbit oral LD50: 370mg \/kg; guinea pig oral LDL0: 120mg\/kg; 2. Other multiple dose toxicity: rabbit oral TDLo: 4500 mg\/kg\/56D-I; rabbit inhalation TCLo: 200 mg\/m3\/7H\/61D-I; guinea pig inhalation TCLo: 200 mg\/m3\/7H\/30D-I; TCLo inhaled by guinea pigs: 25mg\/m3\/7H\/62D-I; 3. Mutagenicity: Mutant microorganism test: Bacteria – Salmonella typhimurium, 3333\u03bcg\/plate; Mutant microorganism test : Klebsiella pneumoniae, 1mmol\/L; mutation test of microorganisms: mouse lymphocytes, 1214mg\/L; mutation test in mammalian body: mouse lymphocytes, 557mg\/L;\n <\/p>\n
This substance is slightly hazardous to water. <\/p>\n<\/p>\n
1. Molar refractive index: 26.96<\/p>\n
2. Molar volume (cm3<\/sup>\/mol): 74.4<\/p>\n3. Isotonic specific volume (90.2K ): 210.4<\/p>\n4. Surface tension (dyne\/cm): 63.9<\/p>\n5. Polarizability (10-24cm3): 10.68<\/p>\n<\/p>\nCompute chemical data<\/h2>\n1.\ufffdReference value for water parameter calculation (XlogP): None<\/P><\/p>\n2. Number of hydrogen bond donors: 1<\/p>\n3. Number of hydrogen bond acceptors: 3<\/p>\n4. Number of rotatable chemical bonds: 0<\/p>\n5. Number of tautomers: 2<\/p>\n6. Topological molecule polar surface area 67.2<\/p>\n7. Number of heavy atoms: 6<\/p>\n8. Surface charge: 0<\/p>\n9. Complexity: 48.1<\/p>\n10. Number of isotope atoms: 0<\/p>\n11. Determine the number of atomic stereocenters: 0<\/p>\n12. Uncertain number of atomic stereocenters: 0<\/p>\n13. Determine the number of chemical bond stereocenters: 0<\/p>\n14. Number of uncertain chemical bond stereocenters: 0<\/p>\n15. Number of covalent bond units: 1<\/p>\n<\/p>\nProperties and stability<\/h2>\n\n Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides, and acid anhydrides.\n <\/p>\nStorage method<\/h2>\n\n Store in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep container tightly sealed. They should be stored separately from oxidants, acids, and food chemicals, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. Suitable materials should be available in the storage area to contain spills.\n <\/p>\nSynthesis method<\/h2>\nIt is obtained by the cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or \u03b1, \u03b2 dichloroethyl ether). Add hot water, thiourea and \u03b1,\u03b2-dichloroethyl ether to the reactor. Reflux with stirring for 2h. Cool and add sodium hydroxide solution through the dropping funnel to make the solution alkaline and precipitate 2-aminothiazole crystals. Then add diethyl ether to dissolve. The ether layer was separated, washed with water, dried over anhydrous sodium sulfate, and the ether was evaporated to obtain crude product. Recrystallize with ethanol to obtain yellow crystals. The yield is 80% and the melting point is 90\u00b0C. <\/p>\n<\/p>\nPurpose<\/h2>\nUsed to synthesize sulfathiazole and antithyroid drugs, and as an intermediate in organic synthesis. <\/p>\n<\/p>\n extended-reading:https:\/\/www.bdmaee.net\/dibutyloxostannane\/<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/120<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44293<\/a><\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/cas-103-83-3-bdma-benzyldimethylamine\/<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/915<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/45062<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44723<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/polyurethane-monosodium-glutamate\/<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40394<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/177<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"Structural formula Business number 02B9 Molecular formu…<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48891,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15337],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48892"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48892"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48892\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48891"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48892"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
3. Isotonic specific volume (90.2K ): 210.4<\/p>\n
4. Surface tension (dyne\/cm): 63.9<\/p>\n
5. Polarizability (10-24cm3): 10.68<\/p>\n<\/p>\n
1.\ufffdReference value for water parameter calculation (XlogP): None<\/P><\/p>\n
2. Number of hydrogen bond donors: 1<\/p>\n
3. Number of hydrogen bond acceptors: 3<\/p>\n
4. Number of rotatable chemical bonds: 0<\/p>\n
5. Number of tautomers: 2<\/p>\n
6. Topological molecule polar surface area 67.2<\/p>\n
7. Number of heavy atoms: 6<\/p>\n
8. Surface charge: 0<\/p>\n
9. Complexity: 48.1<\/p>\n
10. Number of isotope atoms: 0<\/p>\n
11. Determine the number of atomic stereocenters: 0<\/p>\n
12. Uncertain number of atomic stereocenters: 0<\/p>\n
13. Determine the number of chemical bond stereocenters: 0<\/p>\n
14. Number of uncertain chemical bond stereocenters: 0<\/p>\n
15. Number of covalent bond units: 1<\/p>\n<\/p>\n
\n Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides, and acid anhydrides.\n <\/p>\n
\n Store in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep container tightly sealed. They should be stored separately from oxidants, acids, and food chemicals, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. Suitable materials should be available in the storage area to contain spills.\n <\/p>\n
It is obtained by the cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or \u03b1, \u03b2 dichloroethyl ether). Add hot water, thiourea and \u03b1,\u03b2-dichloroethyl ether to the reactor. Reflux with stirring for 2h. Cool and add sodium hydroxide solution through the dropping funnel to make the solution alkaline and precipitate 2-aminothiazole crystals. Then add diethyl ether to dissolve. The ether layer was separated, washed with water, dried over anhydrous sodium sulfate, and the ether was evaporated to obtain crude product. Recrystallize with ethanol to obtain yellow crystals. The yield is 80% and the melting point is 90\u00b0C. <\/p>\n<\/p>\n
Used to synthesize sulfathiazole and antithyroid drugs, and as an intermediate in organic synthesis. <\/p>\n<\/p>\n
extended-reading:https:\/\/www.bdmaee.net\/dibutyloxostannane\/<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/120<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44293<\/a><\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/cas-103-83-3-bdma-benzyldimethylamine\/<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/915<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/45062<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44723<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/polyurethane-monosodium-glutamate\/<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40394<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/177<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"Structural formula Business number 02B9 Molecular formu…<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48891,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15337],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48892"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48892"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48892\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48891"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48892"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Structural formula Business number 02B9 Molecular formu…<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48891,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15337],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48892"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48892"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48892\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48891"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48892"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
![\"2-thiazolamine](\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/05\/592fdf3e3a224dc2a96e547aa3c56739.gif\")
<\/p>\n<\/p>\n